Generic Motilium is utilized to supress nausea and vomiting, and works primarily by blocking dopamine receptors found in the top end of the system that is digestive. This causes tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness, bloating and fullness. It also prevents food from flowing the wrong way through the stomach so prevents reflux (regurgitation of the stomach articles back into the foodpipe).
Unwanted effects include:
Since domperidone is highly metabolised in the liver, domperidone should be utilized with caution in patients with hepatic disability (and in the elderly).
Domperidone must be used with caution in patients with renal impairment or in those at risk of water retention. In patients with severe insufficiency that is renalserum creatinine more than 6mg/100ml, i.e. more than 0,6mmol/L) the elimination half-life of domperidone was increased from 7,4 to 20,8 hours. The dosing frequency should once be reduced to or twice daily, with respect to the severity of impairment, and the dosage may need to be paid down. Patients on prolonged therapy should be reviewed regularly.
Airmail: 2-3 weeks, EMS: 3-8 business days.