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Precautions

Do NOT use Duetact if:

• you're allergic to any ingredient in Duetact
• you might have moderate to severe heart failure, liver problems or abnormal liver function tests, certain severe problems linked to diabetes (eg, diabetic ketoacidosis, diabetic coma), moderate to severe burns, or high blood acid levels (acidosis)
• you've got type 1 diabetes
• you take bosentan.

Contact your physician or health care provider straight away if some of these affect you.

Some health concerns may interact with Duetact. Tell your medical professional or pharmacist for those who have any health concerns, especially if any in the following connect with you:

• if you are pregnant, likely to become pregnant, or are breast-feeding
• in case you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• when you have allergies to medicines, foods, or another substances
• in case you have had a severe hypersensitivity (eg, severe rash, hives, the like, dizziness) to any other sulfonamide medicine such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
• when you have a reputation kidney, thyroid, heart, or circulation system problems; anemia, stroke; certain hormonal problems (eg, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]); low blood sodium levels; or low levels associated with an enzyme called glucose 6-phosphate dehydrogenase (G6PD)
• if you have stomach or bowel problems (eg, stomach or bowel blockage, stomach paralysis), are drinking alcohol, or also have poor nutrition
• when you have very poor health, a top fever, a severe infection, severe diarrhea, high blood acid levels, or brain or central nervous system problems, or also have an intense injury
• for those who have a good bladder cancer, bone fracture, low calcium intake, or weak bones (eg, osteoporosis)
• if you have swelling problems (edema) or certain eye problems (macular edema)
• if you will end up having surgery.

Some medicines may interact with Duetact. Tell your medical provider if you are taking another medicines, especially any with the following:

• Bosentan because liver problems may occur, as well as the effectiveness of both medicines may be decreased
• Beta-blockers (eg, propranolol) since the chance of low blood sugar levels could possibly be increased. They may also hide certain indications of low blood sugar and make it more challenging to notice
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), and sulfonamides (eg, sulfamethoxazole) because the chance of low blood glucose levels may be increased
• Calcium channel blockers (eg, diltiazem), corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, birth control method pills), isoniazid, niacin, phenothiazines (eg, promethazine), phenytoin, rifamycins (eg, rifampin), sympathomimetics (eg, albuterol, epinephrine), or thyroid supplements (eg, levothyroxine) since they may decrease Duetact's effectiveness, resulting in high blood glucose
• Gemfibrozil because blood sugar may be increased or decreased
• Anticoagulants (eg, warfarin) because their effectiveness might be decreased or risk of their unwanted effects could possibly be increased by Duetact.

This is probably not a whole report on all interactions that may occur. Ask your medical provider if Duetact may connect to other medicines that you take. Check with your health care provider before you begin, stop, or customize the dose of the medicine.

Important safety information:

• Duetact might cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects might be worse if you take it with alcohol or certain medicines. Use Duetact with caution. Do not drive or perform other possible unsafe tasks and soon you know how you react to it.
• Do not are drinking alcoholic beverages while you are taking Duetact; it may well raise the chance of low blood sugar. Rarely, alcohol may connect to Duetact and spark a serious reaction with symptoms like flushing, nausea, vomiting, dizziness, or stomach pain. Discuss questions or concerns together with your doctor.
• Carry an ID card at all times that says you've got diabetes.
• Proper eating and working out are essential as a way to slim down and keep it off. Follow the exercise and dieting program given to you from your physician.
• Check your blood glucose levels levels as directed by your doctor. If they are often higher or below they must be so you take Duetact exactly as prescribed, tell your doctor.
• It may be harder to regulate your blood glucose during periods of stress including fever, infection, injury, or surgery. Talk along with your doctor about how to manage your blood sugar if all of these occur. Do not alter the dose of the medicine without checking together with your doctor.
• Do not take over the recommended dose without checking using your doctor.
• Duetact could cause low blood glucose levels levels. Low blood glucose will make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also build your pulse faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It can be a good plan to hold a reliable way to obtain glucose (eg, tablets or gel) to deal with low blood sugar levels. If this is not available, you should eat or drink a quick way to obtain sugar like white sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood glucose level quickly. Tell your medical professional without delay take place. To prevent low blood glucose levels, eat meals concurrently on a daily basis and never skip meals.
• Risk of low blood sugar could be increased by severe or prolonged exercise, having a drink, or skipping meals.
• Duetact contains a sulfonylurea. It may improve the risk of death from coronary disease. Talk along with your doctor in regards to the benefits and risks of this or another therapies to deal with your condition.
• Duetact might cause ovulation in ladies who may have not reached menopause but don't ovulate. To avoid pregnancy, be sure to make use of effective contraception while using Duetact.
• Duetact might cause you to become sunburned with less effort. Avoid the sun, sunlamps, or tanning booths before you discover how you answer Duetact. Use a sunscreen or wear protective clothing in the event you must be outside for greater than a short time.
• Tell your medical professional or dentist that you just take Duetact prior to deciding to have any medical or dental care, emergency care, or surgery.
• Duetact could possibly be associated with an increased probability of bladder cancer. Discuss any questions or concerns with your doctor.
• An increased incidence of bone fracture continues to be reported in females taking Duetact. Tell your physician when you have a good bone fracture, low calcium intake, or weak bones (eg, osteoporosis). Tell your doctor right away in case you experience any unusual bone pain.
• Lab tests, including fasting blood glucose levels, hemoglobin A_1c, liver function, and eye exams, may be performed as you use Duetact. These tests might be used to monitor your condition or search for side effects. Be sure to keep all doctor and lab appointments.
• Use Duetact with caution within the elderly; they might be more responsive to its effects, especially the risk of cardiovascular disease or low blood sugar levels.
• Duetact really should not be employed in children; safety and effectiveness in youngsters have not been confirmed.
• Pregnancy and breast-feeding: Duetact might cause trouble for the fetus or newborn. If you think you could be pregnant, get hold of your doctor. You will need to discuss the rewards and risks of using Duetact while you're pregnant. It is not known if Duetact is located in breast milk. Do not breastfeed while taking Duetact.

When useful for long periods of time Duetact might not are well. If your blood glucose may be in order and then becomes challenging to manage, contact your doctor. Do not change the dose of the medicine without checking together with your doctor.