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Uses

INDICATIONS

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Indinavir is an antiviral medication inside a number of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying within your body. It is used to treat HIV, that causes acquired immunodeficiency syndrome (AIDS). Indinavir just isn't a cure for HIV or AIDS.

INSTRUCTIONS

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Take indinavir exactly as it had been prescribed in your case. Do not make medication in larger amounts, or get it for more than recommended from your doctor. Follow the directions in your prescription label.

This medication incorporates patient instructions for effective and safe use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Take indinavir having a full glass (8 ounces) of water or skim milk. You might also drink juice, coffee, or tea using this type of medication. Drink at least 6 portions of water each day to avoid kidney stones while you're taking indinavir. Indinavir ought to be taken on a clear chair stomach, at least one hour before or 120 minutes after having a meal.

If you want to consider the medication with food, eat simply a light meal, including dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is very important to make use of indinavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To be certain prescription drugs is helping your trouble, your blood will need to be tested on a regular basis. Your liver function could also need to be tested. Do not miss any scheduled visits to your doctor.

HIV/AIDS is generally treated with a combination of different drugs. To best treat your trouble, use all of one's medications as directed because of your doctor. Be sure to read the medication guide or patient instructions furnished with each of your respective medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain within the good care of a health care provider.

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Take the missed dose when you remember and take your next dose in the regularly scheduled time. If you are over couple of hours late in taking your indinavir, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to generate the missed dose.

DOSAGE

Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.


Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis must be initiated immediately, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is among the alternative regimens suited to nonoccupational postexposure HIV prophylaxis.


Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy has to start promptly, preferably within 1 to 2 hours postexposure. The exact use of therapy may differ based on the institution's protocol.

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Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.

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Dose Adjustments
Consider reducing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is given concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence for the prescribed dose is crucial. Patients should not alter the dose or discontinue therapy without conferring with their physician.

Adequate hydration (1.5 liters/day) is crucial during therapy to reduce the potential risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation could possibly be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

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STORAGE

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Store indinavir at room temperature faraway from moisture and heat. Keep the capsules in their original container, combined with the packet of moisture-absorbing preservative that comes with indinavir capsules.

Side Effects

Get emergency medical help if you have these indications of a hypersensitivity: hives; difficulty breathing; swelling of one's face, lips, tongue, or throat. Stop taking indinavir and call your doctor at the same time in case you have these serious unwanted effects:

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Less serious side effects can sometimes include:

This isn't a complete listing of unwanted side effects while others may occur. Tell a medical expert about any unusual or bothersome unwanted effect.

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Precautions

Do not take this medication should you be allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines including ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs might cause life-threatening negative effects if you are using them if you are taking indinavir.

Before taking indinavir, tell your medical professional if you are allergic to any drugs, or if you have:

If you've got some of these conditions, you need a dose adjustment or special tests to soundly take indinavir.
FDA pregnancy category C. This medication could be unhealthy for an unborn baby. Tell your doctor in case you are pregnant or prefer to conceive during treatment. HIV might be passed for the baby if your mother isn't properly treated while pregnant. Take all of your respective HIV medicines as forwarded to overcome your infection when you are pregnant.

Your name may should be from an antiviral pregnancy registry once you begin using prescription drugs.
You should not breast-feed if you are using indinavir. Women with HIV or AIDS shouldn't breast-feed at all. Even if your child comes into the world without HIV, might even pass the herpes virus for the baby within your breast milk.

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