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Uses

INDICATIONS

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Indinavir is definitely an antiviral medication in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying within your body. It is employed to treat HIV, which in turn causes acquired immunodeficiency syndrome (AIDS). Indinavir isn't a cure for HIV or AIDS.

INSTRUCTIONS

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Take indinavir the same manner it had been prescribed for you. Do not go ahead and take medication in larger amounts, or go more than recommended from your doctor. Follow the directions on the prescription label.

This medication includes patient instructions for effective and safe use. Follow these directions carefully. Ask your physician or pharmacist if you have any questions.
Take indinavir using a full glass (8 ounces) of water or skim milk. You could also drink juice, coffee, or tea with this medication. Drink a minimum of 6 portions of water daily to stop kidney stones if you are taking indinavir. Indinavir should be taken on a clear stomach, at the very least an hour before or couple of hours following a meal.

If you prefer to take the medication with food, eat only a light meal, for example dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is vital to work with indinavir regularly to find the most benefit. Get your prescription refilled before you run out of drugs completely.

To make certain prescription drugs is helping your trouble, your blood will have to be tested frequently. Your liver function could also should be tested. Do not miss any scheduled visits to your medical professional.

HIV/AIDS is usually treated using a combination of different drugs. To best treat your problem, use all of your medications as directed by your doctor. Be sure to see the medication guide or patient instructions furnished with each of your medications. Do not alter your doses or medication schedule without advice from your medical professional. Every person with HIV or AIDS should remain beneath the proper a physician.

Take the missed dose when you remember and take the following dose in the regularly scheduled time. If you are a lot more than couple of hours late in taking your indinavir, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to generate the missed dose.

DOSAGE

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Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.

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Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis should be initiated at the earliest opportunity, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is one of the alternative regimens appropriate for nonoccupational postexposure HIV prophylaxis.

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Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy must start promptly, preferably within 1 to a couple of hours postexposure. The exact use of therapy may vary based on the institution's protocol.

Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.

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Dose Adjustments
Consider lowering the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is given concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence on the prescribed dose is vital. Patients should not alter the dose or discontinue therapy without consulting their physician.

Adequate hydration (1.5 liters/day) is crucial during therapy to reduce the potential risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation could be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

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STORAGE

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Store indinavir at room temperature faraway from moisture and heat. Keep the capsules of their original container, with the packet of moisture-absorbing preservative that incorporates indinavir capsules.

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Side Effects

Get emergency medical help for those who have these warning signs of a hypersensitivity: hives; difficulty breathing; swelling of one's face, lips, tongue, or throat. Stop taking indinavir and call a medical expert simultaneously when you have these serious unwanted side effects:

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Less serious unwanted side effects might include:

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This just isn't a complete set of negative effects while others may occur. Tell your doctor about any unusual or bothersome complication.

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Precautions

Do not take this medication in case you are allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines like ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs might cause life-threatening unwanted side effects if you utilize them while you are taking indinavir.

Before taking indinavir, tell your medical professional if you're allergic to any drugs, or if you have:

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If you have these conditions, you might need a dose adjustment or special tests to securely take indinavir.
FDA pregnancy category C. This medication could be harmful to an unborn baby. Tell your medical professional if you're pregnant or prefer to get pregnant during treatment. HIV might be passed to the baby in the event the mother just isn't properly treated during pregnancy. Take all of the HIV medicines as forwarded to moderate your infection while you are pregnant.

Your name may need to be from an antiviral pregnancy registry when you start using prescription drugs.
You should not breast-feed while you are using indinavir. Women with HIV or AIDS should not breast-feed in any way. Even if your child is born without HIV, you'll probably still pass herpes on the baby within your breast milk.

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