Baclofen is used for treating spasm of skeletal muscles that create muscle clonus, rigidity, and pain as a result of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also known as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter inside brain. Neurotransmitters are chemicals that nerves use to convey together. GABA released by some nerves causes the experience of other nerves to diminish. It is considered that Baclofen, acting like GABA, blocks the adventure of nerves inside the area of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.
The usual starting dose of Baclofen for adults is 5 mg thrice daily. Based on the response, the dose can be increased gradually every 72 hours to some maximum of 80 mg/day in many doses.
Baclofen should be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of the reach of kids.
Baclofen might cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low hypertension, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.
Abrupt discontinuation of oral Baclofen might cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).
Use of Baclofen with other drugs that also depress the function of nerves can lead to additional lowering of brain function.
In addition on the risk of depressing brain function, the usage of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together could potentially cause muscle weakness.
Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) can result in greater depression of brain function along with low blood pressure levels.
As Baclofen can increase blood sugar levels, doses of antidiabetic drugs ought to be adjusted when Baclofen is taken.
The use of Baclofen by expecting mothers hasn't been evaluated.
Baclofen may be detected in the breast milk of mothers taking oral Baclofen. No information is positioned on the use of Baclofen within the breast milk of mothers receiving Baclofen intrathecally.
Airmail: 2-3 business weeks
EMS: 3-8 business days
Airmail: 2-3 weeks, EMS: 3-8 business days.