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Uses

INDICATIONS

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Chloroquine is indicated for the suppressive treatment as well as acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated for your treatment of extraintestinal amebiasis.

INSTRUCTIONS

Take chloroquine with meals or milk to lessen stomach upset, unless otherwise directed by your doctor.

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t is vital that you just take chloroquine only as directed. Do not take really it, don't take on it often, and don't take on it for a longer time than your doctor ordered. To do so could raise the probability of serious unwanted effects.

If you adopt chloroquine to maintain you from getting malaria, keep taking it to the regular of treatment. If you have malaria, you should still keep taking chloroquine for the fulltime of treatment even if you set out to feel good soon after days. This will help to clear your infection completely. If you stop taking chloroquine too early, your symptoms may return.

Chloroquine is most effective when you go on it with a regular schedule. For example, if you're to take it once per week in order to avoid malaria, it's always best to get it on the same day every week. Or if you are to take two doses each day, one dose could possibly be taken with breakfast and the other while using evening meal. Make sure that you don't miss any doses. If you might have questions relating to this, check with your wellbeing care professional.

If you miss a dose of chloroquine, go on it immediately. However, if it's almost time for your upcoming dose, skip the missed dose and get back to your regular dosing schedule. Do not double doses.

DOSAGE 

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The dosage of chloroquine phosphate is often expressed with regards to equivalent chloroquine base. Each 500 mg tablet of ARALEN provides the equal of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body mass.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on exactly the same day of per week.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of body mass, but shouldn't exceed the adult dose irrespective of weight.

If circumstances permit, suppressive therapy should begin fourteen days prior to exposure. However, failing this in older adults, a preliminary double (loading) dose of merely one g (= 600 mg base), or perhaps children 10 mg base/kg might be drawn in two divided doses, six hours apart. The suppressive therapy needs to be continued for two months after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of a single g (= 600 mg base) as well as one more 500 mg (= 300 mg base) after six to eight hours plus a single dose of 500 mg (= 300 mg base) on each of two consecutive days. This represents an overall dose of 2.5 g chloroquine phosphate or 1.5 g base in three days.

The dosage for adults of low bodyweight as well as for infants and children needs to be determined as follows:

First dose: 10 mg base per kg (although not exceeding just one dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (although not exceeding an individual dose of 300 mg base).

Third dose: (one day after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy by having an 8-aminoquinoline compound is important.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for just two days, as well as 500 mg (300 mg base) daily not less than two or three weeks. Treatment is usually combined having an effective intestinal amebicide.

STORAGE 

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Store the medicine in the closed container at room temperature, far from heat, moisture, and direct light. Keep from freezing.

Keep from the reach of children.

Do not keep outdated medicine or medicine no more needed.

Side Effects

Along with its needed effects, medicine could potentially cause some uncomfortable side effects. Although not most of these unwanted side effects may occur, should they occur they will often need medical attention. When chloroquine is employed in short periods of time, unwanted effects are often rare. However, when it is employed for quite a while and/or even in high doses, unwanted side effects will occur and may be serious.

Check with your physician immediately if the following negative effects occur:
Less common

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Blurred vision
alteration of vision
eye pain
loss in vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood or any other mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any decrease of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The unwanted side effects in the Less Common category above might also occur or get worse after you stop taking chloroquine.

Some unwanted effects may occur that usually don't need medical assistance. These unwanted side effects might go away during treatment as the body adjusts on the medicine. Also, your health care professional could possibly be able to tell you about ways to stop or reduce some of these unwanted effects. Check with your overall health care professional if the following unwanted effects continue or are bothersome or if you might have any questions about them:


More common


Diarrhea
difficulty in seeing to read
headache
itching (more prevalent in black patients)
lack of appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or inside of mouth
skin rash

Other unwanted effects not listed might also occur in some patients. If you notice any other effects, talk with your health care professional.

Precautions

If you will end up taking chloroquine for quite a while, it is vital that a medical expert check you at regular visits for almost any blood problems or muscle weakness that might be brought on by chloroquine. In addition, check with your physician immediately if blurred vision, difficulty in reading, or any other difference in vision occurs during or after treatment. Your doctor might prefer you to have your eyes checked by an ophthalmologist (eye doctor).

If your symptoms usually do not improve inside a day or two or should they become worse, consult your medical professional.

Make sure you probably know how you respond to chloroquine before you decide to drive, use machines, or do just about anything else that might be dangerous should you be not able to see well.

Chloroquine might cause blurred vision, difficulty in reading, or another change in vision. It may also cause some individuals for being lightheaded.

If these reactions are specially bothersome, consult your medical professional.

Certain medicines should not be used at or around the time of consuming food or eating some kinds of food since interactions may occur. Using alcohol or tobacco with certain medicines might also cause interactions to occur. Discuss together with your healthcare professional using your medicine with food, alcohol, or tobacco.

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There are not any adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in expectant women. Usage of chloroquine during pregnancy must be avoided except in the suppression or treatments for malaria when inside judgment with the physician the benefit outweighs the possible risk towards the fetus.

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