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Uses

INDICATIONS

Chloroquine is indicated for your suppressive treatment as well as acute attacks of malaria on account of P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated for that treating extraintestinal amebiasis.

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INSTRUCTIONS

Take chloroquine with meals or milk to reduce stomach upset, unless otherwise directed from your doctor.

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t is very important that you just take chloroquine only as directed. Do not take more of it, do not take on it more regularly, and don't take on it a bit longer than your physician ordered. To do so could raise the potential for serious negative effects.

If you adopt chloroquine to hold you getting malaria, keep taking it for your full time of treatment. If you already have malaria, you need to still keep taking chloroquine to the full time of treatment although you may begin to feel good right after days. This will help to pay off increase infection completely. If you stop taking chloroquine too soon, your symptoms may return.

Chloroquine is most effective whenever you take it with a regular schedule. For example, should you be to take it weekly to avoid malaria, it is best to take it on the same day each week. Or if you're to adopt two doses every day, one dose may be taken with breakfast as well as the other with all the evening meal. Make sure which you do not miss any doses. If you have any questions about it, talk with your overall health care professional.

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If you miss a dose of chloroquine, get it at the earliest opportunity. However, if it's almost time for your upcoming dose, skip the missed dose and go back to your family dosing schedule. Do not double doses.

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DOSAGE 

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The dosage of chloroquine phosphate is often expressed in terms of equivalent chloroquine base. Each 500 mg tablet of ARALEN provides the same in principle as 300 mg chloroquine base. In infants and children the dosage is preferably calculated by bodyweight.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on exactly the same day of every week.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of weight, but shouldn't exceed the adult dose irrespective of weight.

If circumstances permit, suppressive therapy has to start fourteen days ahead of exposure. However, failing this in adults, a basic double (loading) dose of 1 g (= 600 mg base), or in children 10 mg base/kg might be used two divided doses, six hours apart. The suppressive therapy ought to be continued for two months after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of just one g (= 600 mg base) followed by yet another 500 mg (= 300 mg base) after six to eight hours as well as a single dose of 500 mg (= 300 mg base) on all of two consecutive days. This represents a complete dose of 2.5 g chloroquine phosphate or 1.5 g base in 72 hours.

The dosage for adults of low body mass as well as for infants and children must be determined as follows:

First dose: 10 mg base per kg (but not exceeding just one dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (and not exceeding one particular dose of 300 mg base).

Third dose: (one day after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy with the 8-aminoquinoline compound is critical.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for just two days, followed by 500 mg (300 mg base) daily not less than two or three weeks. Treatment is usually combined with an effective intestinal amebicide.

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STORAGE 

Store the medicine in the closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out from the reach of kids.

Do not keep outdated medicine or medicine will no longer needed.

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Side Effects

Along featuring its needed effects, medicine could cause some unwanted effects. Although not many of these unwanted effects may occur, should they happen they may need medical attention. When chloroquine is employed abbreviated amounts of time, unwanted side effects are frequently rare. However, when it is used for a very long time and/or perhaps high doses, side effects are more inclined to occur and may be serious.

Check with a medical expert immediately if any of the following negative effects occur:
Less common

Blurred vision
alteration of vision
eye pain
loss in vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood or other mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any decrease of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The side effects inside the Less Common category above could also occur or worsen after you stop taking chloroquine.

Some side effects may occur have a tendency to do not need medical help. These unwanted side effects might go away during treatment since your body adjusts towards the medicine. Also, your health care professional could possibly be able to share with you ways to prevent or reduce many of these unwanted effects. Check with your wellbeing care professional if any of the following side effects continue or are bothersome or if you might have any queries about them:

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More common


Diarrhea
difficulty in seeing to read
headache
itching (more widespread in black patients)
loss in appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or inside mouth
skin rash

Other unwanted side effects unlisted may also exist in some patients. If you notice another effects, seek advice from your medical practioner.

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Precautions

If you will end up taking chloroquine for quite a long time, it is vital that your medical professional check you at regular visits for virtually any blood problems or muscle weakness that might be brought on by chloroquine. In addition, talk with your doctor immediately if blurred vision, difficulty in reading, or some other change in vision occurs during or after treatment. Your doctor might want you to definitely have up your eyes checked by an ophthalmologist (eye doctor).

If your symptoms do not improve inside a few days or whenever they become worse, consult a medical expert.

Make sure you probably know how you react to chloroquine prior to deciding to drive, use machines, or a single thing else that might be dangerous if you're not able to see well.

Chloroquine could cause blurred vision, difficulty in reading, or another alteration of vision. It might also cause some individuals for being lightheaded.

If these reactions are especially bothersome, talk with your physician.

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Certain medicines shouldn't be used at or around the time of eating food or eating some types of food since interactions may occur. Using alcohol or tobacco with certain medicines can also cause interactions to occur. Discuss using your medical practioner the application of your medicine with food, alcohol, or tobacco.

There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women. Usage of chloroquine while pregnant needs to be avoided except inside suppression or management of malaria when inside judgment from the physician the power outweighs the opportunity risk to the fetus.

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