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ARAVA is indicated in adults to the treatments for active arthritis rheumatoid (RA):

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Take this medicine only as directed from your doctor. Do not take a greater portion of it, do not take it more often, and do not take on it for a longer period than your medical professional ordered.

The dose of the medicine will be different many different patients. Follow your doctor's orders or the directions around the label. The following information includes only the average doses of this medicine. If your dose differs, usually do not put it back unless your medical professional tells you for this.

The level of medicine that you take depends on the strength with the medicine. Also, the volume of doses you are taking each day, time allowed between doses, and also the time period you're taking the medicine depend around the condition that you can are using the medicine.

For oral dosage form (tablets):

For rheumatoid arthritis symptoms:

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If you miss a dose with this medicine, go on it as soon as possible. However, when it is almost time for your forthcoming dose, skip the missed dose and return to your regular dosing schedule. Do not double doses.


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Store at 25°C (77°F); excursions able to 15-30°C (59-86°F). Protect from light. Keep out of the reach of youngsters. Do not keep outdated medicine or medicine no more needed. Store the medicine inside a closed container at room temperature, away from heat, moisture.

 Keep out in the reach of youngsters. Do not keep outdated medicine or medicine no longer needed. Store the medicine inside a closed container at room temperature, faraway from heat, moisture.


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Side Effects

Stop using this medicine and appearance with your doctor straight away should you be having burning, numbness, tingling, or painful sensations within the arms, hands, legs, or feet. These could be signs of a condition called peripheral neuropathy.

Adverse reactions for this utilization of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along with its needed effects, a medicine could cause some negative effects. Although not most of these unwanted side effects may occur, whenever they happen they could need medical attention.

Check with your doctor immediately if any of the following unwanted side effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
decrease of appetite
nausea / vomiting
sore throat
tightness within the chest
yellow eyes or skin
Less common
Burning feeling in the chest or stomach
burning, prickling, or tingling sensation within the fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
shortness of breath
tenderness in the stomach area
unusual tiredness or weakness
Incidence mysterious
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening from the skin
blood in the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general feeling of tiredness or weakness
high fever
large, hive-like swelling around the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
small of the back or side pain
pains inside the stomach, side, or abdomen, possibly radiating to the back
pale skin
pinpoint red spots on the skin
rapid, shallow breathing
red wounds, often using a purple center
red, irritated eyes
sores, ulcers, or white spots inside mouth or about the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness inside arms, hands, legs, or feet

Some side effects may occur that usually tend not to need medical attention. These unwanted effects might have to go away during treatment as the body adjusts on the medicine. Also, your health care professional just might let you know about approaches to prevent or reduce some of these unwanted effects. Check with your health care professional if any from the following unwanted effects continue or are bothersome or if you might have questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness in the mouth
itching with the skin
pain or burning inside the throat
runny nose

Other unwanted side effects not listed may also appear in some patients. If you notice every other effects, check using your health care professional.



It is vital that your physician look at your progress at regular visits to ensure that this medicine is functional. Blood tests are usually necesary to test for uncomfortable side effects.

Using this medicine while you're pregnant may damage your child. Use an effective way of birth control to help keep from conceiving. If you think you've got get pregnant with the medicine, tell a medical expert without delay.

Leflunomide may also cause birth defects in the event the father is using it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms being a type of contraception during intercourse. A man going to father a youngster should stop investing in this medicine and check along with his doctor without delay.

Serious skin reactions may appear using this medicine. Stop employing this medicine and check with your doctor without delay if you've any with the following symptoms while investing in this medicine: blistering, peeling, or loosening from the skin; chills; itching; joint or muscle pain; red skin lesions, often with a purple center; sores, ulcers, or white spots inside the mouth or about the lips; or unusual tiredness or weakness.

Liver problems may occur while you are employing this medicine. Stop by using this medicine and appearance with a medical expert immediately should you be having more than one of the symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; loss in appetite; nausea or vomiting; skin rash; swelling in the feet or legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the amount of white blood cells within your blood, increasing the probability of getting infection. It can also lower the quantity of platelets, that are necessary for proper blood clotting. If this occurs, there are particular precautions it is possible to take, particularly if your blood count is low, to lessen the potential risk of infection or bleeding:

Check with a medical expert straight away if you have a cough with or without temperature, difficulty breathing, or any difficulty with breathing.

You will need to have a skin test for tuberculosis before you begin using this medicine. Tell your doctor if you or anyone in your home has ever endured a confident reply to a tuberculosis test.

Using this medicine may improve your probability of getting serious infections or cancer. Talk to a medical expert if you've got concerns relating to this risk.

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Do not take other medicines unless they are discussed with a medical expert. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamins.

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