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ARAVA is indicated in adults for that management of active rheumatism (RA):

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Take this medicine only as directed by your doctor. Do not take much more of it, don't take on it more frequently, and don't take it for a longer time than your doctor ordered.

The dose of this medicine vary many different patients. Follow your doctor's orders or perhaps the directions about the label. The following information includes only the average doses of the medicine. If your dose differs, tend not to change it unless your doctor lets you know to do so.

The quantity of medicine which you take depends on the strength in the medicine. Also, the number of doses you take each day, enough time allowed between doses, and the time period you take the medicine depend about the disease that you can are choosing the medicine.

For oral dosage form (tablets):

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For arthritis rheumatoid:

If you miss a dose of this medicine, go as quickly as possible. However, whether it is almost time for your upcoming dose, skip the missed dose and return to your normal dosing schedule. Do not double doses.

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Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F). Protect from light. Keep out in the reach of children. Do not keep outdated medicine or medicine no longer needed. Store the medicine in the closed container at room temperature, faraway from heat, moisture.

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 Keep out with the reach of kids. Do not keep outdated medicine or medicine will no longer needed. Store the medicine in the closed container at room temperature, away from heat, moisture.

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Side Effects

Stop using this medicine and check with your medical professional without delay should you be having burning, numbness, tingling, or painful sensations inside arms, hands, legs, or feet. These could be signs of a condition called peripheral neuropathy.

Adverse reactions for this usage of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

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Along having its needed effects, medication could potentially cause some uncomfortable side effects. Although not these unwanted side effects may occur, if they do occur they might need medical help.

Check with your doctor immediately if any from the following unwanted effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
loss of appetite
sore throat
tightness in the chest
yellow eyes or skin
Less common
Burning feeling inside chest or stomach
burning, prickling, or tingling sensation inside fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
shortness of breath
tenderness inside stomach area
unusual tiredness or weakness
Incidence mysterious
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
blood inside stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general sense of tiredness or weakness
high fever
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
lower back or side pain
pains within the stomach, side, or abdomen, possibly radiating towards the back
pale skin
pinpoint red spots around the skin
rapid, shallow breathing
red lesions on the skin, often having a purple center
red, irritated eyes
sores, ulcers, or white spots inside mouth or for the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness inside arms, hands, legs, or feet

Some side effects may occur have a tendency to do not need medical attention. These negative effects might go away during treatment because your body adjusts towards the medicine. Also, your wellbeing care professional just might inform you of solutions to prevent or reduce a few of these unwanted side effects. Check with your health care professional if any with the following side effects continue or are bothersome or if you might have questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness in the mouth
itching with the skin
pain or burning within the throat
runny nose

Other unwanted effects unlisted can also appear in some patients. If you notice some other effects, check along with your health care professional.

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It is critical that your physician look at your progress at regular visits to ensure that this drugs are functional. Blood tests are usually necesary to check for negative effects.

Using this medicine while you're pregnant can harm your unborn baby. Use an effective kind of birth control method to keep from conceiving. If you think you've get pregnant when using the medicine, tell your physician straight away.

Leflunomide could also cause birth defects in the event the father is employing it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms as being a type of birth control method during sex. A man going to father a young child should stop using this medicine and check together with his doctor straight away.

Serious skin reactions can happen using this medicine. Stop by using this medicine and check with your medical professional without delay if you've any with the following symptoms while using this medicine: blistering, peeling, or loosening of the skin; chills; itching; joint or muscle pain; red lesions on the skin, often which has a purple center; sores, ulcers, or white spots in the mouth or about the lips; or unusual tiredness or weakness.

Liver problems may occur while you are employing this medicine. Stop applying this medicine and appearance with a medical expert right away if you are having more than one of those symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; decrease of appetite; queasiness; skin rash; swelling with the feet or calves; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the number of white blood cells with your blood, helping the chance of getting an infection. It can also lower the number of platelets, which can be needed for proper blood clotting. If this occurs, there are specific precautions you are able to take, particularly when your blood count is low, to reduce the chance of infection or bleeding:

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Check with your doctor right away if you've a cough with or without temperature, breathlessness, or any difficulty with breathing.

You needs to have a skin test for tuberculosis before you begin applying this medicine. Tell your doctor in the event you or anyone inside your home has had a good response to a tuberculosis test.

Using this medicine may increase your chance of getting serious infections or cancer. Talk to a medical expert if you've got concerns concerning this risk.

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Do not take other medicines unless they've been discussed with your medical professional. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or nutritional vitamin supplements.

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