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Precautions

Do NOT use Clozaril if:

• you're allergic to the ingredient in Clozaril
• you might have bone marrow problems, other blood cell problems, or perhaps a good blood problems a result of Clozaril
• you've uncontrolled seizures (eg, epilepsy) or loss in bowel muscle movement (paralytic ileus)
• you have severe drowsiness
• you consider other medicines that may cause blood problems. Ask your medical professional in case you are unsure if all of your medicines could cause blood problems.

Contact your doctor or doctor right away if all of these sign up for you.

Some health conditions may talk with Clozaril. Tell your physician or pharmacist in case you have any medical conditions, particularly when any of the following sign up for you:

• if you're pregnant, likely to conceive, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, and other substances
• if you have a good blood clots, blood problems, high blood blood choleseterol levels, heart problems, or lung or breathing problems
• for those who have a history of your enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel problems; or dementia
• if you have poor health, diabetes, or perhaps a relative with diabetes, or you're very overweight
• when you have decreased activity of enzymes that metabolize certain medicines.

Some medicines may connect to Clozaril. Tell your health care provider if you take any other medicines, especially any in the following:

• Benzodiazepines (eg, lorazepam) or another medicines for mental or mood problems since the probability of heart or breathing problems could be increased
• Cimetidine, erythromycin, quinolone antibiotics (eg, ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they might increase the chance of Clozaril's negative effects
• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), nicotine, or rifampin since they may decrease Clozaril's effectiveness
• Antiarrhythmics (eg, propafenone, quinidine), anticholinergics (eg, benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure levels, phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) since the probability of their negative effects may be increased by Clozaril.

This is probably not a total list of all interactions that could occur. Ask your health care provider if Clozaril may connect to other medicines that you just take. Check with your physician before you start, stop, or affect the dose of any medicine.

Important safety information:

• Clozaril could cause drowsiness, dizziness, or lightheadedness. These effects could be worse if you take it with alcohol or certain medicines. Use Clozaril with caution. Do not drive or perform other possible unsafe tasks unless you recognize how you answer it.
• Do not use alcohol or medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) as you taking Clozaril. It may improve their effects. Ask the pharmacist in case you have queries about which medicines might cause drowsiness.
• Clozaril could potentially cause dizziness, lightheadedness, or fainting; alcohol, summer, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lay down with the first manifestation of any of these effects.
• Clozaril may lower the ability of the body to address infection. Avoid exposure to people who have colds or infections. Tell your medical professional right away possibly any signs of infection like fever, sore throat, rash, chills, mouth or nose sores, or unusual tiredness or weakness.
• Women and patients of Jewish background might be at greater likelihood of developing blood difficulty with Clozaril.
• If you might have a history of seizures, you might suddenly lose conscious as you are taking Clozaril. Avoid activities through which decrease of conscious could possibly be dangerous to you personally forms of languages (eg, driving, swimming, climbing, operating machinery).
• Clozaril may increase your blood glucose. High blood glucose levels will make you're feeling confused, drowsy, or thirsty. It can also cause you to flush, breathe faster, or use a fruit-like breath odor. If these symptoms occur, tell a medical expert right away.
• Avoid drink and food full of caffeine, like coffee, tea, cocoa, cola, and chocolate.
• Tell your physician or dentist that you just take Clozaril. It could have an effect on the medical or dentistry, emergency care, or surgery you might receive.
• Neuroleptic malignant syndrome (NMS) can be a possibly fatal syndrome that can be due to Clozaril. Symptoms can include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact your physician at once if you have any of these symptoms.
• Some patients taking Clozaril may develop muscle movements which they cannot control. This is more prone to happen in elderly patients, especially women. The chance until this will happen or that it'll become permanent is greater in those who take Clozaril in high doses and quite a long time. Muscle problems might also occur after short-term treatment with low doses. Tell your doctor immediately when you have muscle problems with your tongue, face, mouth, jaw (eg, tongue herniated, puffing of cheeks, mouth puckering, chewing movements), arms, or legs while taking Clozaril.
• Lab tests, including complete blood cell counts and heart function tests, may be performed to watch your progress or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Clozaril with caution within the elderly; they could be more sensitive to its effects, especially blood problems, dizziness (especially upon standing), fast heartbeat, urinary problems, and constipation.
• Clozaril ought to be in combination with warning in youngsters; safety and effectiveness in kids are not determined.
• Pregnancy and breast-feeding: If you conceive, contact your doctor. You will need to discuss the huge benefits and perils of using Clozaril while you might be pregnant. It is not known if Clozaril is located in breast milk. Do not breastfeed while taking Clozaril.