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Duloxetine is used to take care of anxiety and depression. In addition, duloxetine is employed to greatly help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to health conditions such as arthritis, chronic right back pain, or fibromyalgia (a condition that causes widespread pain).

Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It may also decrease pain because of certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the mind.

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OTHER USES: This part contains uses of this drug that are perhaps not listed in the approved labeling that is professional the drug but which could be prescribed by your health care pro. Use this drug for a condition that is placed in this part as long as it is often therefore recommended by your wellbeing care professional.

This medicine may also be used to help treat other painful nerve conditions (neuropathic pain).

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Read the Medication Guide and, if available, the Patient Information Leaflet given by your pharmacist before you start using duloxetine and each time you get a refill. If you have any relevant questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your physician, usually 1 or 2 times a day with or without food. It may help to take this drug with food if you have nausea. Swallow the capsule whole. Don't crush or chew the capsule or mix the contents with liquid or food. Doing so can release all the drug at once, increasing the risk of side effects.

The dosage is dependant on your age, medical problem and response to treatment. To reduce your threat of side effects, your doctor may direct you to definitely start this medicine at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Take this medication regularly to get the benefit that is most from this. To aid you remember, just take it during the same time(s) each day.

It's important to continue taking this medicine as prescribed even in the event that you feel well. Do not stop taking this medicine without consulting your physician. Some conditions could become worse whenever this drug is abruptly stopped. Also, you may experience observable symptoms such as for example dizziness, confusion, mood swings, headache, tiredness, diarrhea, rest changes, and brief emotions just like electric shock. Your dose may need to be gradually decreased to reduce side impacts. Report any new or worsening symptoms right away.

Tell your physician if the condition persists or worsens.

Side Effects

See section that is also warning.

Nausea, dry lips, constipation, loss of appetite, tiredness, drowsiness, or increased sweating may occur. If some of these impacts persist or worsen, tell your doctor quickly.

Dizziness or lightheadedness may possibly occur, particularly whenever you first start or increase your dose of this drug. To reduce the risk of dizziness, lightheadedness, or falling, get up slowly when rising from a sitting or position that is lying.

Remember that your physician has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious adverse effects.

This medication might raise your blood pressure. Check your blood pressure regularly and tell your doctor if the total answers are high.

Inform your doctor right away if some of these serious side results occur: confusion, easy bruising/bleeding, decreased interest in sex, alterations in sexual ability, muscle cramps/weakness, shaking (tremor), difficulty urinating, unusual decrease into the amount of urine, signs of liver problems (such as stomach/abdominal pain, persistent sickness, vomiting, yellowing eyes/skin, dark urine).

Get medical help straight away if you have got any very severe side effects, including: black/bloody stools, vomit that appears like coffee grounds, seizure, eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night, blurred vision).

This medication may increase serotonin and rarely cause an extremely serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away in the event that you develop some of the next symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, serious nausea/vomiting/diarrhea, twitching muscles, unexplained temperature, uncommon agitation/restlessness.

a really serious allergic reaction to this drug is rare. However, get help that is medical away if you notice any symptoms of a serious allergic response, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, difficulty breathing, skin blisters, mouth sores.

This really is not a list that is complete of side effects. If you notice other effects not listed above, contact your pharmacist or doctor.

In the US -

Phone your doctor for medical advice about part effects. You may report effects that are side FDA at 1-800-FDA-1088 or at

In Canada - Phone your doctor for medical advice about part effects. You might report side effects to Health Canada at 1-866-234-2345.


Before taking duloxetine, inform your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which could cause allergic reactions or other problems. Speak to your pharmacist to get more details.

Before applying this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of psychiatric disorders (such as for instance bipolar/manic-depressive condition), personal or family history of suicide attempts, bleeding problems, personal or family members history of glaucoma (angle-closure type), hypertension, renal disease, liver disease, seizure disorder, stomach problems (such as slow emptying of this stomach), use/abuse of alcohol.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

When you yourself have diabetes, duloxetine may affect your glucose levels. Check your blood sugar frequently as directed by your doctor. Your medical professional may require to regulate your diabetes medication, exercise regime, or diet.

Before having surgery, tell your physician or dentist about all the services and products you employ (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the relative adverse effects of this drug, especially bleeding, dizziness, lightheadedness, or loss of coordination. Older adults may be more likely also to develop a form of salt imbalance (hyponatremia), particularly when they are taking "water pills" (diuretics). Dizziness, lightheadedness, or loss of coordination can boost the threat of falling.

Young ones may be more sensitive to the relative side effects of this drug, especially loss of appetite and weight loss. Monitor height and weight in children who are taking this drug. See also Warning.

During pregnancy, this medication should really be used only once clearly needed. It may harm an unborn baby. Also, babies born to mothers who have used this drug during the last 3 months of pregnancy may develop withdrawal symptoms rarely such as feeding/breathing difficulties, seizures, muscle tightness, or constant crying. If you notice any one of these symptoms in your newborn, promptly tell the doctor.

Since untreated mental/mood dilemmas (such as depression, anxiety) may be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss the benefits and risks of using this medication during pregnancy with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your physician before breast-feeding.

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