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Precautions

Do NOT use Endep if:

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• you are allergic to the ingredient in Endep
• you are currently taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine, selegiline) within the past 14 days

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• you take antihistamines (eg, diphenhydramine), cisapride, droperidol, a ketolide (eg, telithromycin) , a macrolide (eg, erythromycin), mibefradil, or pimozide
• you are recovering from a heart attack.

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Contact your medical professional or doctor immediately if some of these affect you.

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Some medical conditions may interact with Endep. Tell your doctor or pharmacist for those who have any health concerns, particularly if any of the following affect you:

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• if you are pregnant, about to conceive, or are breast-feeding

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• if you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement

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• for those who have allergies to medicines, foods, or another substances

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• if you have a history of mental illness (eg, bipolar disorder, mania, manic-depression), or consider or attempted suicide

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• in case you have alcoholism or regularly consume 3 or more alcoholic beverages per day

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• when you have glaucoma, an irregular heartbeat, cardiovascular disease, chest pain, liver disease, prostate problems, thyroid disease, or can't seem to urinate (urinary retention)

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• in case you have a reputation seizures, epilepsy, or porphyria.

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Some medicines may connect to Endep. Tell your doctor if you are taking another medicines, especially any in the following:

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• MAOIs (eg, phenelzine, selegiline) simply because they may cause serious, sometimes life-threatening, reactions. Do not take MAO inhibitors with, or within fourteen days of taking, Endep

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• Anticholinergics (eg, scopolamine), bupropion, cimetidine, fluconazole, phenothiazines (eg, chlorpromazine), SSRIs (eg, fluoxetine), terbinafine, or valproic acid because unwanted effects like blurred vision, difficult urination, drowsiness or sedation, dry mouth, or lightheadedness may occur

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• Antihistamines (eg, diphenhydramine), cisapride, droperidol, ketolides (eg, telithromycin), macrolides (eg, erythromycin), mibefradil, pimozide, or streptogramins (eg, quinupristin/dalfopristin) because serious unwanted side effects around the heart (eg, racing heartbeat, dizziness, fainting, life-threatening abnormal heartbeat resulting in unconsciousness, and insufficient heartbeat, could possibly be increased by Endep
• Carbamazepine, thyroid medicines (eg, levothyroxine), or stimulants (eg, albuterol, pseudoephedrine) because their unwanted side effects could be increased by Endep

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• Warfarin because unwanted effects including serious bleeding may be increased by Endep
• Clonidine, guanethidine, or guanfacine because the effectiveness of the medicines may be decreased.

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This will not be a total set of all interactions that could occur. Ask your medical provider if Endep may communicate with other medicines which you take. Check with your health care provider when you start, stop, or alter the dose of the medicine.

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Important safety information:

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• Endep may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything whatsoever else that could be dangerous until you know how you reply to Endep. Using Endep alone, with medicines, or with alcohol may lessen your skill to drive or perform other very dangerous tasks.

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• Avoid drinking alcohol or taking other medicines that create drowsiness (eg, sedatives, tranquilizers) while taking Endep. Endep will add towards the connection between alcohol and also other depressants. Ask the pharmacist if you have questions regarding which medicines are depressants.

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• Endep could cause dizziness, lightheadedness, or fainting; alcohol, warm weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, specially in the morning. Sit or lie down at the first symbol of all of these effects.

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• Involuntary and uncontrollable movements may develop in patients taking Endep. Occurrence is highest one of the elderly, especially women. The risk of developing these involuntary movements along with the likelihood they will become permanent are increased with long-term use along with high doses. However, it is possible to develop these symptoms after short-term use at low doses. Contact your medical provider immediately if any of the following occur: involuntary movements from the tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes associated with involuntary movements from the legs and arms.

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• Endep could cause sensitivity to sunlight. Avoid prolonged exposure for the sun along with other ultraviolet light (eg, tanning beds). Use sunscreens and wear protective clothing until tolerance is established.

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• Do not become overheated in hot weather or during exercise and other activities since heatstroke may occur.

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• Diabetes patients - Endep may affect your blood glucose. Check blood sugar levels levels closely. Ask your doctor prior to deciding to customize the dose of your respective diabetes medicine.

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• Before you have any medical or dental treatments, emergency care, or surgery, tell your physician or dentist that you will be using Endep.

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• Use caution in the elderly; they might be more sensitive to its effects, especially lightheadedness upon standing; rapid heartbeat; breathing problems; difficult urination; and constipation.

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• Pregnancy and breast-feeding: Endep has been shown to cause harm to the human fetus. If you plan on becoming pregnant, consult with your doctor the huge benefits and perils of using Endep while pregnant. Endep is excreted inside breast milk. Do not breastfeed while taking Endep.

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