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Precautions

Do NOT use Zestoretic if:

• you are allergic to your ingredient in Zestoretic or other sulfonamide medicine (eg, sulfamethoxazole, glyburide, probenecid)
• you use a reputation angioedema (swelling of the face, lips, throat, or tongue)
• you have a very reputation kidney artery narrowing

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• you can't urinate

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• you consider dofetilide or ketanserin
• you might be pregnant.

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Contact your physician or doctor straight away if all of these sign up for you.

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Some health concerns may connect to Zestoretic. Tell your physician or pharmacist if you have any health concerns, in particular when any in the following sign up for you:

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• if you might be pregnant, likely to become pregnant, or are breast-feeding

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• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• when you have allergies to medicines, foods, or other substances

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• if you're able to become pregnant
• if you have impaired liver function, blood vessel problems (eg, stroke), coronary disease (eg, congestive heart failure), or high cholesterol

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• in case you have a reputation kidney artery narrowing or decreased kidney function, you're on dialysis, or you might have had a kidney transplant
• in case you have gout, diabetes, or electrolyte imbalances (eg, high or low potassium levels, low blood sodium levels), or you're with a sodium-restricted diet
• if you have a very collagen vascular disorder (eg, lupus, scleroderma), bone marrow problems, or severe disease fighting capability problems

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• in case you have a very good reputation for allergies or asthma

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• if you are scheduled to possess major surgery or receive anesthesia.

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Some medicines may talk with Zestoretic. Tell your doctor in the event you are taking any other medicines, especially any with the following:

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• Aldosterone blockers (eg, eplerenone), corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, lithium, loop diuretics (eg, furosemide), potassium preparations, potassium-sparing diuretics (eg, triameterene), or trimethoprim because the chance of electrolyte problems and irregular heartbeat may be increased

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• Barbiturates (eg, phenobarbital), dextran sulfate, diazoxide, or narcotic pain medicine (eg, codeine) because the chance of low blood pressure might be increased
• Gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low hypertension may occur
• Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) given that they may decrease Zestoretic's effectiveness
• Insulin, sulfonylureas (eg, glyburide), or other medicines for diabetes (eg, metformin) his or her effectiveness may be decreased by Zestoretic.

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This is probably not a whole listing of all interactions that may occur. Ask your doctor if Zestoretic may communicate with other medicines that you adopt. Check with your health care provider before you start, stop, or alter the dose of any medicine.

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Important safety information:

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• Zestoretic may cause dizziness, lightheadedness, or fainting. These effects might be worse if you adopt it with alcohol or certain medicines. Use Zestoretic with caution. Do not drive or perform other possible unsafe tasks until you know how you react into it.
• Zestoretic could potentially cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, crunch or stand slowly, especially inside morning. Sit or lie down on the first sign associated with a of these effects.

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• Check using your doctor prior to deciding to use a salt substitute or perhaps a creation that has potassium within it.
• Drink a good amount of fluids while taking Zestoretic and avoid participating in activities that cause sweating. Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in hypertension. Contact your doctor at the same time if any of these occur.

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• Diabetes patients - Zestoretic may raise your blood sugar. High blood glucose may make you really feel confused, drowsy, or thirsty. It can also allow you to flush, breathe faster, or possess a fruit-like breath odor. If these symptoms occur, tell a medical expert right away.

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• A persistent, unproductive cough may occur. Tell your physician if it occurs. Recovery is rapid when the medicine is stopped.

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• Patients who take medicine for high blood pressure often feel tired or rundown for a few weeks after starting treatment. Be sure to take your medicine even though you may well not feel "normal." Tell your doctor if you develop any new symptoms.

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• Zestoretic might not act as well in black patients. They may be also at greater chance of negative effects. Contact your doctor if your symptoms do not improve or if they become worse.

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• Tell your medical professional or dentist that you take Zestoretic when you have any medical or dentistry, emergency care, or surgery.

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• Zestoretic may cause you to become sunburned easier. Avoid the sun, sunlamps, or tanning booths until you understand how you react to Zestoretic. Use a sunscreen or wear protective clothing in the event you should be outside for more than a short time.

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• Zestoretic may obstruct certain lab tests, including parathyroid function tests. Be sure your medical professional and lab personnel know you take Zestoretic.
• Lab tests, including blood electrolytes, hypertension, complete blood cell counts, and kidney function, may be performed while you use Zestoretic. These tests could possibly be used to monitor your condition or pay attention to side effects. Be sure to keep all doctor and lab appointments.
• Use Zestoretic with caution inside the elderly; they could possibly be more sensitive to its effects.
• Zestoretic needs to be used with extreme caution in kids; safety and effectiveness in youngsters are not confirmed.

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• Pregnancy and breast-feeding: Zestoretic could potentially cause birth defects or fetal death if you're taking it while you're pregnant. If you think you could possibly be pregnant, speak to your doctor right away. Zestoretic is located in breast milk. Do not breastfeed while taking Zestoretic.

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