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Precautions

Do NOT use Zestoretic if:

• you happen to be allergic to the ingredient in Zestoretic or any other sulfonamide medicine (eg, sulfamethoxazole, glyburide, probenecid)
• you have a good angioedema (swelling of the face, lips, throat, or tongue)
• you use a good kidney artery narrowing
• you cannot urinate
• you take dofetilide or ketanserin
• you are pregnant.

Contact your medical professional or health care provider straight away if all of these sign up for you.

Some health conditions may interact with Zestoretic. Tell a medical expert or pharmacist when you have any health conditions, in particular when any in the following affect you:

• if you happen to be pregnant, planning to become pregnant, or are breast-feeding
• if you consider any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• for those who have allergies to medicines, foods, or other substances
• if you might be able to become pregnant
• in case you have impaired liver function, blood vessel problems (eg, stroke), cardiovascular disease (eg, congestive heart failure), or high cholesterol
• in case you have a history of kidney artery narrowing or decreased kidney function, you might be on dialysis, or you have had a kidney transplant
• for those who have gout, diabetes, or electrolyte imbalances (eg, high or low potassium levels, low blood sodium levels), or you are on a sodium-restricted diet
• in case you use a collagen vascular disorder (eg, lupus, scleroderma), bone marrow problems, or severe body's defence mechanism problems
• in case you have a very good allergies or asthma
• if you happen to be scheduled to have major surgery or receive anesthesia.

Some medicines may connect to Zestoretic. Tell your health care provider if you take any other medicines, especially any with the following:

• Aldosterone blockers (eg, eplerenone), corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, lithium, loop diuretics (eg, furosemide), potassium preparations, potassium-sparing diuretics (eg, triameterene), or trimethoprim because the risk of electrolyte problems and irregular heartbeat could possibly be increased
• Barbiturates (eg, phenobarbital), dextran sulfate, diazoxide, or narcotic pain medicine (eg, codeine) as the likelihood of low blood pressure could possibly be increased
• Gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low hypertension may occur
• Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) given that they may decrease Zestoretic's effectiveness
• Insulin, sulfonylureas (eg, glyburide), or other medicines for diabetes (eg, metformin) because their effectiveness could possibly be decreased by Zestoretic.

This is probably not a whole set of all interactions that may occur. Ask your medical provider if Zestoretic may interact with other medicines that you adopt. Check with your doctor before starting, stop, or customize the dose of the medicine.

Important safety information:

• Zestoretic might cause dizziness, lightheadedness, or fainting. These effects may be worse if you adopt it with alcohol or certain medicines. Use Zestoretic with caution. Do not drive or perform other possible unsafe tasks unless you know how you react to it.
• Zestoretic may cause dizziness, lightheadedness, or fainting; alcohol, warm weather, exercise, or fever may increase these effects. To prevent them, crunches or stand slowly, especially within the morning. Sit or lie down at the first sign of any of these effects.
• Check using your doctor before you use a salt substitute or a creation that has potassium inside it.
• Drink lots of fluids while taking Zestoretic and steer clear of starting activities that create sweating in excess. Dehydration, sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your doctor simultaneously if some of these occur.
• Diabetes patients - Zestoretic may raise your blood sugar levels. High blood sugar will make you are feeling confused, drowsy, or thirsty. It can also cause you to be flush, breathe faster, or use a fruit-like breath odor. If these symptoms occur, tell a medical expert without delay.
• A persistent, unproductive cough may occur. Tell your doctor if this occurs. Recovery is rapid if the medicine is stopped.
• Patients taking medicine for high blood pressure often feel tired or rundown for a couple of weeks after starting treatment. Be sure to take your medicine even though you might not feel "normal." Tell your physician in the event you develop any new symptoms.
• Zestoretic may not act as well in black patients. They may even be at greater chance of unwanted effects. Contact your doctor in case your symptoms usually do not improve or if they become worse.
• Tell your medical professional or dentist that you are taking Zestoretic before you decide to get any medical or dental hygiene, emergency care, or surgery.
• Zestoretic could potentially cause you to become sunburned easier. Avoid the sun, sunlamps, or tanning booths until you understand how you react to Zestoretic. Use a sunscreen or wear protective clothing if you must be outside for more than a small amount of time.
• Zestoretic may obstruct certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Zestoretic.
• Lab tests, including blood electrolytes, blood pressure level, complete blood cell counts, and kidney function, might be performed when you use Zestoretic. These tests may be used to monitor your condition or pay attention to unwanted effects. Be sure to keep all doctor and lab appointments.
• Use Zestoretic with caution within the elderly; they might be more responsive to its effects.
• Zestoretic must be in combination with extreme caution in youngsters; safety and effectiveness in youngsters haven't been confirmed.
• Pregnancy and breast-feeding: Zestoretic could cause birth defects or fetal death if you adopt it while you might be pregnant. If you think you might be pregnant, get hold of your doctor right away. Zestoretic can be found in breast milk. Do not breastfeed while taking Zestoretic.