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Mestinon (Pyridostigmine) affects chemicals by the body processes which are active in the communication between nerve impulses and muscle movement.

Pyridostigmine is used to help remedy the signs and symptoms of myasthenia gravis. It is also found in military personnel who have been confronted with nerve gas.

Pyridostigmine may also be used for purposes unpublished in this medication guide.

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Take just as prescribed from your doctor. Do not take in larger or smaller amounts and longer than recommended. Follow the directions on your own prescription label.
Take this medicine with food or milk whether or not this upsets your stomach. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking or opening the pill might cause a lot of drug to be released at one time.

Measure liquid medicine having a special dose measuring spoon or medicine cup, not using a regular table spoon. If you do not use a dose measuring device, ask your pharmacist for one.

The amount and timing of the drugs are very important to the success of the treatment. Carefully follow your medical professional's instructions about how precisely much medicine to take when to adopt it.

Your doctor may occasionally make positive changes to dose to ensure that you get the best results. You may be motivated to keep a daily record of whenever you took each dose and just how long the consequences lasted. This will help a medical expert determine if your dose must be adjusted.
If you need surgery, tell the surgeon in advance that you're using pyridostigmine. You may need to stop using the medicine for the short time. Store at room temperature from moisture and warmth.

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Take the medicine as prescribed through your doctor.


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Keep the tablets of their original container, with the canister of moisture-absorbing preservative that is included with this medicine.

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Active ingredient: Pyridostigmine

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Side Effects

Get emergency medical help when you have some of these warning signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using pyridostigmine and call a medical expert at the same time for those who have all of these serious unwanted effects:

extreme muscle weakness, muscle twicthing;

slurred speech, vision problems;

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severe vomiting or diarrhea;

cough with mucus;

confusion, anxiety, panic attacks;

seizure (convulsions); or

worsening or no improvement within your signs and symptoms of myasthenia gravis.

Less serious side effects can include:

cold sweat, pale skin;

urinating more than usual;

watery eyes;

mild nausea, vomiting, or upset stomach;

warmth or tingly feeling; or

mild rash or itching.

This just isn't a complete list of unwanted effects among others may occur. Call a medical expert for medical health advice about unwanted effects.

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You must avoid using pyridostigmine if you are allergic with it, or if you use a bladder or bowel obstruction.

To make sure you can safely take pyridostigmine, tell your doctor in case you have all of these other conditions:


kidney disease;

an ulcer and other serious stomach disorder;

high hypertension, heart disease;

overactive thyroid; or

a history of seizures.

It isn't known whether pyridostigmine will harm an baby. Tell a medical expert if you're pregnant or prefer to become pregnant with all the medicines. It just isn't known whether pyridostigmine passes into breast milk or if it could harm a nursing baby. Do not use prescription drugs without telling a medical expert if you are breast-feeding your baby.

Drugs interaction 

Tell your doctor about all the medicines you use, especially:

atropine (Atreza, Sal-Tropine);

belladonna (Donnatal, and others);

benztropine (Cogentin);

clidinium (Quarzan);

clozapine (Clozaril, FazaClo);

dimenhydrinate (Dramamine);

methscopolamine (Pamine), scopolamine (Transderm Scop);

glycopyrrolate (Robinul);

mepenzolate (Cantil);

bladder or urinary medications including darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

bronchodilators for example ipratropium (Atrovent) or tiotropium (Spiriva);

cold medicine, allergy medicine, or sleeping pills that contain an antihistamine such as diphenhydramine (Tylenol PM) or doxylamine (Unisom);

heart rhythm medication such as quinidine (Quin-G), procainamide (Procan, Pronestyl), disopyramide (Norpace), flecaininde (Tambocor), mexiletine (Mexitil), propafenone, (Rythmol), among others;

irritable bowel medications for example dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine);

medicine to help remedy Alzheimer's dementia, for example donepezil (Aricept), rivastigmine (Exelon), or tacrine (Cognex); or

a steroid including betamethasone (Celestone) or dexamethasone (Cortastat, Dexasone, Solurex, DexPak).

This list is not complete and other drugs may connect to pyridostigmine. Tell your medical professional about all medications you have. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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