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ARAVA is indicated in adults for the treatment of active rheumatoid arthritis symptoms (RA):


Take this medicine only as directed through your doctor. Do not take a greater portion of it, don't take it more frequently, and don't take on it for a longer period than your physician ordered.

The dose with this medicine will be different for several patients. Follow your doctor's orders or even the directions for the label. The following information includes merely the average doses on this medicine. If your dose is different, tend not to put it back unless a medical expert informs you to do so.

The level of medicine that you just take depends around the strength of the medicine. Also, the number of doses you adopt each day, enough time allowed between doses, and the length of time you take the medicine depend about the medical problem for which you are utilizing the medicine.

For oral dosage form (tablets):

For rheumatoid arthritis symptoms:

If you miss a dose of the medicine, take it as quickly as possible. However, whether it is almost time for your forthcoming dose, skip the missed dose and go back to your family dosing schedule. Do not double doses.


Store at 25°C (77°F); excursions able to 15-30°C (59-86°F). Protect from light. Keep out with the reach of kids. Do not keep outdated medicine or medicine no longer needed. Store the medicine in the closed container at room temperature, from heat, moisture.

 Keep out from the reach of youngsters. Do not keep outdated medicine or medicine no longer needed. Store the medicine in the closed container at room temperature, far from heat, moisture.


Side Effects

Stop by using this medicine and check with a medical expert right away in case you are having burning, numbness, tingling, or painful sensations inside arms, hands, legs, or feet. These could be signs of a condition called peripheral neuropathy.

Adverse reactions for this utilization of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along having its needed effects, medication might cause some unwanted side effects. Although not all of these unwanted side effects may occur, whenever they do occur they could need medical help.

Check with your doctor immediately if any in the following unwanted side effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
decrease of appetite
sore throat
tightness inside the chest
yellow eyes or skin
Less common
Burning feeling inside chest or stomach
burning, prickling, or tingling sensation inside fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
lack of breath
tenderness inside the stomach area
unusual tiredness or weakness
Incidence mysterious
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening from the skin
blood within the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a sense tiredness or weakness
high fever
large, hive-like swelling for the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
back or side pain
pains inside the stomach, side, or abdomen, possibly radiating towards the back
pale skin
pinpoint red spots around the skin
rapid, shallow breathing
red lesions on the skin, often having a purple center
red, irritated eyes
sores, ulcers, or white spots in the mouth or around the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness inside the arms, hands, legs, or feet

Some unwanted side effects may occur have a tendency to do not need medical help. These unwanted side effects might go away during treatment as the body adjusts to the medicine. Also, your wellbeing care professional may be able to let you know about solutions to prevent or reduce many of these negative effects. Check along with your health care professional if any with the following unwanted side effects continue or are bothersome or if you have questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness from the mouth
itching with the skin
pain or burning within the throat
runny nose

Other negative effects unpublished might also happen in some patients. If you notice every other effects, check along with your health care professional.



It is very important that your physician check your progress at regular visits to make certain that this medicine is working properly. Blood tests are usually necesary to check on for uncomfortable side effects.

Using this medicine if you are pregnant can harm your unborn baby. Use an effective way of birth control to help keep from conceiving a child. If you think you have get pregnant while using the medicine, tell a medical expert without delay.

Leflunomide can also cause birth defects when the father is using it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms as a form of contraceptive during intercourse. A man planning to father a child should stop taking this medicine and check regarding his doctor right away.

Serious skin reactions can occur using this medicine. Stop using this medicine and appearance with your physician immediately if you might have any of the following symptoms while investing in this medicine: blistering, peeling, or loosening from the skin; chills; itching; joint or muscle pain; red wounds, often with a purple center; sores, ulcers, or white spots inside the mouth or on the lips; or unusual tiredness or weakness.

Liver problems may occur while you are choosing this medicine. Stop by using this medicine and look with your doctor right away in case you are having more than one of these symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; loss of appetite; nausea or vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the quantity of white blood cells inside your blood, improving the potential for getting infection. It can also lower the volume of platelets, that are required for proper blood clotting. If this occurs, a number of precautions you'll be able to take, especially when your blood count is low, to cut back the chance of infection or bleeding:

Check with your doctor right away if you have a cough with or without nausea, shortness of breath, or any risk with breathing.

You have to have a skin test for tuberculosis before you start using this medicine. Tell your medical professional if you or anyone within your home has ever had a positive reply to a tuberculosis test.

Using this medicine may improve your probability of getting serious infections or cancer. Talk to a medical expert if you have concerns relating to this risk.

Do not take other medicines unless to remain discussed with your physician. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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