Baclofen is employed for treating spasm of skeletal muscles that induce muscle clonus, rigidity, and pain as a result of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also known as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter inside the brain. Neurotransmitters are chemicals that nerves use to speak collectively. GABA released by some nerves causes the experience of other nerves to lower. It is considered that Baclofen, acting like GABA, blocks the adventure of nerves within the part of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was authorized by the FDA in November, 1977.
The usual starting dose of Baclofen for adults is 5 mg thrice daily. Based on the response, the dose can be increased gradually every three days with a maximum of 80 mg/day in several doses.
Baclofen should be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of your reach of kids.
Baclofen could cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.
Abrupt discontinuation of oral Baclofen could cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).
Use of Baclofen with other drugs that also depress the function of nerves may result in additional lowering of brain function.
In addition on the chance of depressing brain function, using Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together could potentially cause muscle weakness.
Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) can lead to greater depression of brain function as well as low hypertension.
As Baclofen can increase blood glucose levels, doses of antidiabetic drugs might need to be adjusted when Baclofen is taken.
The using Baclofen by pregnant women hasn't been evaluated.
Baclofen could be detected in the breast milk of mothers taking oral Baclofen. No details are positioned on the use of Baclofen inside the breast milk of mothers receiving Baclofen intrathecally.
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