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Baclofen is utilized for treating spasm of skeletal muscles that create muscle clonus, rigidity, and pain due to multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (otherwise known as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter inside the brain. Neurotransmitters are chemicals that nerves use to speak collectively. GABA released by some nerves causes the activity of other nerves to lower. It is thought that Baclofen, acting like GABA, blocks the game of nerves from the part of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was authorized by the FDA in November, 1977.
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The usual starting dose of Baclofen for adults is 5 mg 3 times daily. Based on the response, the dose may be increased gradually every 3 days to some maximum of 80 mg/day in a number of doses.
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Baclofen should be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of the reach of children.
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Baclofen might cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.
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Abrupt discontinuation of oral Baclofen might cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).
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Use of Baclofen to drugs which also depress the function of nerves can lead to additional lowering of brain function.
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In addition towards the chance of depressing brain function, the application of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together may cause muscle weakness.
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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) can lead to greater depression of brain function and also low blood pressure levels.
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As Baclofen can increase blood glucose, doses of antidiabetic drugs ought to be adjusted when Baclofen is taken.
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The using Baclofen by pregnant women is not evaluated.
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Baclofen can be detected in the breast milk of mothers taking oral Baclofen. No info is entirely on the existence of Baclofen inside the breast milk of mothers receiving Baclofen intrathecally.
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